The Adoption of Blockchain Technologies in Data Sharing: A State of the Art Survey

In the big data era, it is a significant need for data sharing in various industries. However, there are many weaknesses in the traditional centralized way of data sharing. It is easy to attack the centralized data storage center. As the process of data asset transactions is not transparent, there is a lack of trust in the percipients of data sharing. Blockchain technology offers a possibility to solve these problems in data sharing, as the blockchain can provide a decentralized, programmable, tamperproof, and anonymous data sharing environment. In this paper, we compare the blockchain-based data sharing with the traditional ways of data sharing, and analyze the scenarios in major industry applications. We survey the state of the art of the adoption of blockchain technologies in data sharing, and provide a summary about their technical frameworks and schemes

Oral vinorelbine and continuous low doses of cyclophosphamide in pediatric rhabdomyosarcoma: a real-world study

Introduction: Metronomic maintenance therapy (MMT) has significantly improved the survival of patients with high-risk rhabdomyosarcoma in clinical trials. However, there remains a lack of relevant data on its effectiveness in real-world situations.Methods: We retrospectively retrieved data of 459 patients < 18 years of age diagnosed with rhabdomyosarcoma at Sun Yat-sen University Cancer Center from January 2011 to July 2020 from our database. The MMT regimen was oral vinorelbine 25–40 mg/m2 for twelve 4-week cycles on days 1, 8, and 15, and oral cyclophosphamide 25–50 mg/m2 daily for 48 consecutive weeks.Results: A total of 57 patients who underwent MMT were included in the analysis. The median follow-up time was 27.8 (range: 2.9–117.5) months. From MMT to the end of follow-up, the 3-year PFS and OS rates were 40.6% ± 6.8% and 58.3% ± 7.2%, respectively. The 3-year PFS was 43.6% ± 11.3% in patients who were initially diagnosed as low- and intermediate-risk but relapsed after comprehensive treatment (20/57), compared with 27.8% ± 10.4% in high-risk patients (20/57) and 52.8% ± 13.3% in intermediate-risk patients who did not relapse (17/57). The corresponding 3-year OS for these three groups was 65.8% ± 11.4%, 50.1% ± 12.9%, and 55.6% ± 13.6%, respectively.Conclusion: We present a novel study of MMT with oral vinorelbine and continuous low doses of cyclophosphamide in real-world pediatric patients with RMS. Our findings showed that the MMT strategy significantly improved patient outcomes and may be an effective treatment for high-risk and relapsed patients

Patterns of pediatric and adolescent female genital inflammation in China: an eight-year retrospective study of 49,175 patients in China

BackgroundGenital inflammation is one of the most frequent clinical complaints among girls, which was easily overlooked by the general public. This study aimed to investigate the patterns and epidemiological characteristics of pediatric and adolescent female genital inflammation in China.MethodsA retrospective observational study (2011 to 2018) was conducted among all female patients under the age of 0–18 years at the Department of Pediatric and Adolescent Gynecology of The Children’s Hospital, Zhejiang University School of Medicine. Data were collected from the electronic medical records. The abnormal vaginal discharge of patient was collected for microbiological investigation by bacterial and fungal culture. Descriptive analysis was conducted to evaluate the genital inflammation pattern and epidemiological characteristics, including age, season, and type of infected pathogens.ResultsA total of 49,175 patients met the eligibility criteria of genital inflammation and 16,320 patients later came to the hospital for follow-up over the study period. The number of first-visit increased gradually from 3,769 in 2011 to 10,155 in 2018. The peak age of the first visit was 0–6 years old. Non-specific vulvovaginitis, lichen sclerosis, and labial adhesion were the top three genital inflammation. Among the top five potential common pathogens of vaginal infection, the prevalence of Haemophilus influenzae cases was the highest (31.42%, 203/646), followed by Streptococcus pyogenes (27.74%, 176/646), Candida albicans (14.09%, 91/646), Escherichia coli (8.51%, 55/646), and Staphylococcus aureus (6.35%, 41/636). The specific disease categories and pathogens of genital inflammation vary by age groups and season.ConclusionOur study summarizes the pattern of pediatric and adolescent female genital inflammation over an 8-year period in China, emphasizing the need for more public awareness, healthcare services and research in this field

Research and Design of a high-efficiency Class-F Power Amplifier

Power amplifiers are important parts in communication systems. They are often used at the end of the transmitter and the front of the receiver. Research on power amplifiers is also developing fast. Expect for linear power amplifiers, switch-mode power amplifiers have been popular among the high-efficiency power amplifiers designers. Basic theories and performance parameters of power amplifiers, as well as classification of the amplifiers are introduced in this thesis. Then the research background and basic structure of Class-F power amplifiers are introduced in detail. Class-F power amplifiers have the advantage of high efficiency, because its ideal drain output voltage and current are square and half-sine waveforms with a phase difference of 180º. In this way, the overlap area is cut down and the power consumed by the transistor is reduced. This thesis uses the Advanced Design System (ADS) software to get the best direct current quiescent operation point of the transistor, and then get the impedance of the transistor at different harmonics through the Load-pull and Source-pull template. Based on the data collected, a harmonic control circuit is designed with compensating of the parasites to raise the efficiency of the amplifier. After getting the final input and output matching network, we finally get the schematic of the designed Class-F power amplifier. According to the optimized schematic, the simulation result is when the input power is 33 dBm, the output power is 41.64 dBm at the frequency of 2.45 GHz. And the power added efficiency is 81.75%, which achieves the design goal. Considering second and third harmonics needed to be controlled, the whole size of the network will be large, over 10 cm in length. So research about design of a compact Class-F power amplifier is done. Associated with the low-pass filter structure, simplified real frequency technique (SRFT) is used to calculate the parameters of the matching network, which can achieve of the aimed value of the transducer power gain (TPG). Such a method can match the impedance well, as well as control the harmonics effectively. The simulation result of the final optimized compact Class-F power amplifier is when the input power is 33 dBm, the output power is 42 dBm at the frequency of 2.45 GHz, with a power added efficiency (PAE) of 80.51%. The design achieves the design goal and effectively cut the size of the whole circuit. The final size of the circuit is 5 cm x 6 cm. Then a co-simulation of layout and schematic is done in ADS. Compared with schematic simulation, the result of co-simulation is more accurate and help reduce some possible errors before fabricating. The result of layout co-simulation can reach a PAE of 64.23%. Keyword: High-efficiency, Class-F power amplifier, SRF

Estimation of Forest Canopy Height and Aboveground Biomass from Spaceborne LiDAR and Landsat Imageries in Maryland

Mapping the regional distribution of forest canopy height and aboveground biomass is worthwhile and necessary for estimating the carbon stocks on Earth and assessing the terrestrial carbon flux. In this study, we produced maps of forest canopy height and the aboveground biomass at a 30 m spatial resolution in Maryland by combining Geoscience Laser Altimeter System (GLAS) data and Landsat spectral imageries. The processes for calculating the forest biomass included the following: (i) processing the GLAS waveform and calculating spatially discrete forest canopy heights; (ii) developing canopy height models from Landsat imagery and extrapolating them to spatially contiguous canopy heights in Maryland; and, (iii) estimating forest aboveground biomass according to the relationship between canopy height and biomass. In our study, we explore the ability to use the GLAS waveform to calculate canopy height without ground-measured forest metrics (R2 = 0.669, RMSE = 4.82 m, MRE = 15.4%). The machine learning models performed better than the principal component model when mapping the regional forest canopy height and aboveground biomass. The total forest aboveground biomass in Maryland reached approximately 160 Tg. When compared with the existing Biomass_CMS map, our biomass estimates presented a similar distribution where higher values were in the Western Shore Uplands region and Folded Application Mountain section, while lower values were located in the Delmarva Peninsula and Allegheny Mountain regions

Evaluation and Comparison of Light Use Efficiency and Gross Primary Productivity Using Three Different Approaches

Light use efficiency (LUE), which characterizes the efficiency with which vegetation converts captured/absorbed radiation into organic dry matter through photosynthesis, is a key parameter for estimating vegetation gross primary productivity (GPP). Studies suggest that diffuse radiation induces a higher LUE than direct radiation in short-term and site-scale experiments. The clearness index (CI), described as the fraction of solar incident radiation on the surface of the earth to the extraterrestrial radiation at the top of the atmosphere, is added to the parameterization approach to explain the conditions of diffuse and direct radiation in this study. Machine learning methods—such as the Cubist regression tree approach—are also popular approaches for studying vegetation carbon uptake. This paper aims to compare and analyze the performances of three different approaches for estimating global LUE and GPP. The methods for collecting LUE were based on the following: (1) parameterization approach without CI; (2) parameterization approach with CI; and (3) Cubist regression tree approach. We collected GPP and meteorological data from 180 FLUXNET sites as calibration and validation data and the Global Land Surface Satellite (GLASS) products and ERA-interim data as input data to estimate the global LUE and GPP in 2014. Site-scale validation with FLUXNET measurements indicated that the Cubist regression approach performed better than the parameterization approaches. However, when applying the approaches to global LUE and GPP, the parameterization approach with the CI became the most reliable approach, then closely followed by the parameterization approach without the CI. Spatial analysis showed that the addition of the CI improved the LUE and GPP, especially in high-value zones. The results of the Cubist regression tree approach illustrate more fluctuations than the parameterization approaches. Although the distributions of LUE presented variations over different seasons, vegetation had the highest LUE, at approximately 1.5 gC/MJ, during the whole year in equatorial regions (e.g., South America, middle Africa and Southeast Asia). The three approaches produced roughly consistent global annual GPPs ranging from 109.23 to 120.65 Pg/yr. Our results suggest the parameterization approaches are robust when extrapolating to the global scale, of which the parameterization approach with CI performs slightly better than that without CI. By contrast, the Cubist regression tree produced LUE and GPP with lower accuracy even though it performed the best for model validation at the site scale

Multiple Bismuth Quadruple Therapy Containing Tetracyclines Combined with Other Antibiotics and <i>Helicobacter pylori</i> Eradication Therapy

Helicobacter pylori (HP) infection is closely associated with the development of chronic gastritis, peptic ulcer, and gastric cancer. However, the resistance rate of H. pylori strains to antibiotics such as clarithromycin, metronidazole, and levofloxacin has increased significantly, resulting in a significant decrease in the eradication efficacy of commonly used regimens. Tetracycline has received the attention of domestic and foreign scholars because of its low resistance. The purpose of this review is to provide an update on the tetracycline-containing bismuth quadruple eradication therapy for H. pylori infection and review the efficacy and safety of the regimens, hoping to provide guidance for clinical practice

Magma Evolution and Constraints on the Graphite Mineralization Hosted by the Huangyangshan Alkaline Granite Suite in the East Junggar of Xinjiang Province: Evidence from In Situ Analyses of Silicate Minerals

The Huangyangshan super-large graphite deposit, located in the East Junggar area of the Xinjiang Province, is hosted in and has closely temporal, spatial, and genetic relationships with the Huangyangshan alkaline granites. There are such silicate minerals as amphibole, biotite, pyroxene, and plagioclase occurring in the graphite-bearing granites. The integration of the electron microprobe analysis (EMPA) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) enabled us to reveal the physicochemical conditions and evolution process, as well as the relationship of alkaline magmatism with graphite mineralization. The results show that the amphiboles generally have low Al and high Ti, K, Si, and Fe contents, as well as similar rare-earth elements (REEs) patterns and trace element distribution patterns to granites with significantly negative Eu anomalies. In the analyzed samples, primary biotite belongs to Fe-biotite and has characteristics of high Si and Fe and low Al and Mg contents. In the graphite orbicules, the pyroxene phenocrysts develop multiple zonal structures and are characterized by high Si and low Ca and Fe contents. The dominant plagioclase phenocrysts in the graphite orbicules are oligoclase and andesine, with normal and occasionally oscillatory zoning. The calculated crystallization temperature of the pyroxene, amphibole, and primary biotite in graphite orbicules are 840–1012 °C, 681–761 °C, and 658–720 °C, respectively, corresponding with their crystallization order. The pressure and depth calculation results of the amphibole, representing those of the magmatism, are 157–220 Mpa and 5.95–8.32 km, respectively. Both amphibole and biotite crystallized in a reducing environment with extremely low oxygen fugacity. The elemental compositions of these silicates indicate that the Huangyangshan pluton experienced significant mixing of mafic mantle-derived magma and felsic crust-derived magma. The cores of graphite orbicules were formed in a relatively earlier magmatic stage, while the granites and their dioritic enclaves were formed in a later magmatic stage. During magmatism, the mixing of mantle-derived basic magma had an important influence on the evolution and differentiation of the melts. According to the coexisting sulfides with graphite and compositional difference of amphibole and biotite in the granites and graphite ores, the graphite mineralization might be triggered by a magma mixing process

Effect of Bonding Temperature on Microstructure and Mechanical Properties during TLP Bonding of GH4169 Superalloy

The effect of bonding temperature on the microstructure and mechanical properties of transient liquid phase (TLP) joints of GH4169 superalloy was investigated. Joining processes were carried out at 1040&ndash;1100 &deg;C for 30 min using BNi-2 solder paste. The results showed that three distinct microstructural zones were formed in the joint region: an athermal solidification zone (ASZ), consisting of eutectic compounds; an isothermal solidification zone (ISZ), consisting of &gamma; solid solution; and a diffusion affected zone (DAZ), consisting of Ni-Cr rich boride and Cr-Nb-Mo-rich boride compounds. With increasing bonding temperature, the amounts of eutectic compounds in ASZ first decreased and then increased. A eutectic-free joint centerline was obtained at 1080 &deg;C. The maximum bonding shear strength reached 728.03 MPa due to the completion of isothermal solidification. Fractographic studies revealed that the boride compounds in ASZ and the intermetallic compounds in DAZ were the main causes for the failure of joints. The fracture mode of the sample bonded at 1040 &deg;C was brittle, and the fracture path was along the ASZ. However, the fracture mode of the sample bonded at 1080 &deg;C was ductile, and the fracture occurred along the DAZ

Energy-Saving Potential Comparison of Different Photovoltaic Integrated Shading Devices (PVSDs) for Single-Story and Multi-Story Buildings

Building-integrated photovoltaic (BIPV) façades are a promising technique for improving building energy performance. This study develops energy simulation models of different photovoltaic-integrated shading devices (PVSDs) in single-story and multi-story office buildings. A cross-region study in China is carried out to explore the energy performance of PVSDs in five climate zones. The shading effect of the upper PVSDs is taken into account. The results show that (1) PVSDs can be applicable in hot and cold climates; shading effects lead to a notable difference in the optimal PVSDs style. The average comprehensive energy saving ratios of different PVSDs ranged from 16.12% (fixed PV louvres in the vertical plane) to 51.95% (lower single panel). The most rewarding PVSDs are for single-story buildings in Kunming and the least suitable are for multi-story buildings in Guangzhou. (2) In climate zones with little air-conditioning energy consumption, avoiding considerably increased lighting consumption by PVSDs is vital. (3) To reduce shading effects, solar panels with smaller widths or vertical placements can be adopted. In addition, the distance of the PV modules from the top edge of the windows is also critical. Building performance evaluation in the early design stage enables maximum benefits for the same input (total area of PV panels). The research methodology and data analysis presented can guide parameters design and the geographical applicability of PVSDs, providing a reference for optimal building energy performance